Instantiate prefab with different values each time

The "Instantiate" function returns a reference to the object that was created. Just store that reference into a variable and make any change you want:

 using UnityEngine;

 public class Test() {
     GameObject prefab;
 
     void Start() {
         GameObject clone = (GameObject)Instantiate(prefab);
         clone.name = "I'm a clone of the prefab".
         Debug.Log(clone.name);
         GameObject clone2 = (GameObject)Instantiate(prefab);
         clone2.name = "I'm a different clone".
         Debug.Log(clone2.name);
     }
 
 }

Edit: Sorry, I just read you instantiate a prefab with 4 childs, you can iterate over the childs of any object using it's Transform, look here: http://answers.unity3d.com/questions/10417/how-can-i-access-the-children-of-a-transform.html

Storing the reference after the instantiation of the prefab and iterating over the childs like shown in that link you should be able to change any value of each child.

Generally speaking it is bad practice to use GameObject.Find() because it kills frame rate if used frequently. The better practice is to maintain a reference to the GameObject. I believe, in your case (correct me if I am wrong) you have one prefab and that prefab has four children, and you want to modify some values in the children. (I am going to assume you are modifying their transforms, but you can add a reference for any Component type.)

The following will allow you to drag and drop the child elements in to the array on the prefab. From there you can modify them however you want in code.

 public class MyObject : MonoBehaviour
 {
     [SerializeField] private Transform[] children; 
 
     public void Start() 
     {
         // Modify each child Transform here ...
     }
 }
 

You can iterate through children of the GameObject.

http://docs.unity3d.com/ScriptReference/Transform-childCount.html http://docs.unity3d.com/ScriptReference/Transform.GetChild.html

Or post your code :)

There are design patterns called the factory patterns that are exactly for this:

Unity Implementation:

https://www.patrykgalach.com/2019/03/28/implementing-factory-design-pattern-in-unity/1

More info:

https://www.youtube.com/watch?v=EcFVTgRHJLM&t=1s

https://www.youtube.com/watch?v=v-GiuMmsXj4