Can I replace the source image of slices by script?

I have a prefab that uses slices from a single PNG. (in animation clips). If I replace that PNG in the Finder, all slices taken from that PNG are automatically updated, which is great.

But I want to do this by script: just replace the PNG where all slices are taken from, with another PNG. This is so that each of my prefabs instances can all use a different spritesheet PNG source for its slices.