Spritesheet or deactivate some sprites?

Which would work better? Big spritesheet or deactivating unwanted sprites at the start of the animation? If I wanted to make an object whose animation is 10 moving shapes, but if the player presses the key, these shapes will change. Should I make a big spritesheet or deactivate 10 unwanted objects at the start of the animation? I would prefer the second solution to make the animation look nicer but I don't know if it would put a load on the computer if I used this method with other objects.