Can you rotate individual quads that were created via a mesh through C#?

So I want to make an isometric 2D game. The sprites for the ground are not square as they were drawn to be in isometric view. (example: http://flarerpg.org/tutorials/isometric_intro/tile_sizes.png )

Now I found a tutorial ( by quill18creates on youtube) to create 1 mesh with individual tiles and each tile can use a specific sprite to color that specific tile. Because my sprites are already created with an isometric view, there will be a blank section between each sprite.

So my question is: Is it possible to rotate individual quads (not the entire object) so when The camera views them from an isometric angle, that my isometric sprites will align correctly?

I would like to have one mesh for these floor sprites instead of creating thousands of gameobjects with quads each with their own script that needs to be updated every time a ground sprite is changed. OR if there is a different more efficient way of doing this, could you point me in the right direction?