Are animation clips frame dependant?

What I mean is, if for example you create a keyframe that activates a GameObject and a few frames later another to deactivate it, are they guaranteed to fire even if the frame rate drops and one (or both) gets skipped?

I know animation events are guaranteed to fire, but are keyframed properties too?

Just trying to know if it's safe to put game logic inside the animations this way, but can't find anything regarding this.