Unity crashes with serial ports

I'm working on a project which uses a lot of serial devices (11) with data being written nearly every frame. Unfortunately, Unity will regularly crash when there are problems with this sending, and I get a com port unavailable error or a "device has stopped working" error. Does Unity have problems with dealing with serial ports in this way? I think it is likely my computer not being able to handle all the USB devices (which there is other evidence of), but wanted to check if there could be a problem on the unity side. Anyone have best practices for dealing with this sort of problem?