Long-term installation & memory leaks. Force full restart?

I'm using a Unity application in a long-term installation. Small memory leaks build up over time and begin slowing down the application. I realize I could hunt down every last memory leak, but I'm wondering if there is a way to occasionally restart the Unity application, completely releasing everything from memory and starting from a fresh state.

I've already tried restarting my scene and using Resources.UnloadUnusedAssets() but memory leaks persist. Thanks for any ideas in advance.