Addressables Correctly release gameobject which has also another addressable component

Let's say I have Addressable prefab "itemReference". "itemReference" has a sprite component and the sprite itself is another addressable as well. If I want to Destroy itemReference what is a proper way to do it?

This is instantiate code of itemReference:

 var spritesHandle = Addressables.LoadAssetsAsync<Sprite>(keys, (sprite) =>
         {
             itemReference.InstantiateAsync(layoutGroup).Completed += (handle) =>
             {
                 var go = handle.Result;
                 go.transform.Find("Image").GetComponent<Image>().sprite = sprite;
                 go.transform.Find("Text").GetComponent<Text>().text = sprite.name;
             };
         }, Addressables.MergeMode.Union);

Then when I am done and want to release all itemReference gameObjects I am doing this:

 foreach (Transform item in layoutGroup.transform)
   {
             Addressables.ReleaseInstance(item.gameObject);
    }

but this doesn't clear the memory it only destroys the game objects from the scene.

If I first release sprite handle and then release itemReference gameObjects it clears the memory correctly. But I don't know if this is a correct way to do it.

 Addressables.Release(spritesHandle);
 foreach (Transform item in layoutGroup.transform)
     {
         Addressables.ReleaseInstance(item.gameObject);
     }