Deleting prefab located in Project in scripts

Hi, I am trying to edit a prefab located in the Project (on the hard drive) and doing some delete operations (such as Destroy a Component). But when I try to do that with DestroyImmediate, I got a "Destroying assets is not permitted to avoid data loss" error and I fail to modify the prefab.

Is there any work around with this without using DestroyImmediate()? I was thinking to create a instance of the prefab and then apply the change back to the prefab, but this does not work for cases where the GameObject is a child of the prefab.

Thanks.

Here is a sample code of what I am doing DestroyImmediate(Prefab.GetComponent()); where Prefab is the GameObject prefab.