Sprite2D texture memory optimization

Hey Guys, I have a lot of sprite atlases, because I'm doing a sprite animation that is really long. I have set all my textures to max 1024 and compressed, but when I use the profiler, they take a lot more memory than they actually to with their file size. Would any of you guys have an idea how I could optimize my memory with this. I make sure that I only have the necessary memory in use by using Resources.UnloadUnusedAssets, but I still got too much memory. I can't afford it if I want to run on mobile. I tried to put my sprite sheet in power of two and maybe expect that it would reduce my memory, but in fact, in ended up taking more memory.

Thanks a lot for your time :)

Claude