Unknown Error

Every time I load up my unity game I get this Error.

Internal compiler error. See the console log for more information. output was: Unhandled Exception: System.UnauthorizedAccessException: Access to the path "C:\Users\Jamie\Desktop\Unity Projects\Jump and Shoot Man\Temp\Assembly-CSharp.dll.mdb" is denied.

at System.IO.FileStream..ctor (System.String path, FileMode mode, FileAccess access, FileShare share, Int32 bufferSize, Boolean anonymous, FileOptions options) [0x00000] in :0

at System.IO.FileStream..ctor (System.String path, FileMode mode, FileAccess access, FileShare share, Int32 bufferSize, Boolean isAsync, Boolean anonymous) [0x00000] in :0

at System.IO.FileStream..ctor (System.String path, FileMode mode, FileAccess access) [0x00000] in :0

at Mono.CompilerServices.SymbolWriter.MonoSymbolWriter.WriteSymbolFile (Guid guid) [0x00000] in :0

at Mono.CSharp.SymbolWriter+SymbolWriterImpl.WriteSymbolFile () [0x00000] in :0

at Mono.CSharp.SymbolWriter.WriteSymbolFile () [0x00000] in :0

at Mono.CSharp.CodeGen.Save (System.String name, Boolean saveDebugInfo, Mono.CSharp.Report Report) [0x00000] in :0

at Mono.CSharp.Driver.Compile () [0x00000] in :0

at Mono.CSharp.Driver.Main (System.String[] args) [0x00000] in :0

I have no idea what is wrong and it has never done this before to me, if anybody here was any knowledge of how I can go about stopping this from happening I would be very grateful.

Thank You