Does the unity save automatically any local file?

So, I have this project, and I'm using onGUI on it. I set the position of some objects with the GUITexture. So to I don't have any trouble with the position 'cause of the resolution, I set the resolution to don't be resizable and fullscreen, and then I built. I open the .exe and it works fine, but when I plugged another monitor to my pc and stopped to work. Now it doesn't work at all. I'd like to know if the unity save any local file in the pc when I execute the .exe like cache or something like that.

Please help meee D: