Isometric projectile collision 2D or 3D?

If I wanted to remake diablo 2 in unity. I would make the game in 2D for better performance. My question is, can I use a tilemap to check for projectile collisions in an isometric game? I know I can probably write my own system from scratch, but I am curious if this can be handled with a system already in unity.

If this would not work, how would I best utilize a 2D collider with an isometric camera set up in unity?