Are there any implications of bad performance with large scale?

Based on recent readings I've switched the size of my orthographic camera from something extremely small (8-12ish) to half the height of the screen. Because the orthographic size is so much larger I'm required to scale up all my objects quite a bit. Should I be cautious for any performance hits when it comes to lighting or anything working with a much larger scale?

Could the functions such as Transform.translate use more resource?