SetScriptingDefineSymbolsForGroup working is strange

My app crashed by "UNITY_DEBUG" define.

In some situation, "UNITY_DEBUG" define is not applied while generate methods_pointedto_by_uievents.xml.

(I guess methods_pointedto_by_uievents.xml was related Unity Inspector logic)

It occured when first build without "UNITY_DEBUG" define and then next build with "UNITY_DEBUG" define.

I use "SetScriptingDefineSymbolsForGroup" API before call "BuildPipeline.BuildPlayer.

Following is pseduo code and test steps.

Step 1. build "Release"

[AutoBuilder.cs]

 // Apply Defines
         PlayerSettings.SetScriptingDefineSymbolsForGroup(BuildTargetGroup.Android, "SOME_DEFINES");
         
 // Run Build
 BuildPipeline.BuildPlayer(GetScenePaths(), buildTargetPath, BuildTarget.Android, options);

Step 2. build "Debug"

[AutoBuilder.cs]

 // Apply Defines
 PlayerSettings.SetScriptingDefineSymbolsForGroup(BuildTargetGroup.Android, "UNITY_DEBUG;SOME_DEFINES");
 
 // Run Build
 BuildPipeline.BuildPlayer(GetScenePaths(), buildTargetPath, BuildTarget.Android, options);

Step 3. run my app created in Step 2.

Crash! It caused by nothing functions definition about UNITY_DEBUG define in methods_pointedto_by_uievents.xml (see attached under image)

Following is pseduo code of the functions

[DebugMgr.cs / class DebugMgr]

 #if UNITY_DEBUG
 public void ShareMail()
 {
 }
 
 public void ShowNativeShare()
 {
 }
 ... ...
 #endif

Left side is methods_pointedto_by_uievents.xml of good.(debug)

Right side is methods_pointedto_by_uievents.xml of crashed.(also debug)

There is no functions of "DebugMgr(under UNITY_DEBUG define)" and caused by it.

but, once again build debug mode, the "DebugMgr" code generated in methods_pointedto_by_uievents.xml (Left side)

In summary

1. Release build -> Debug build -> Crashd! (Right side)

2. Release build -> Debug build -> Debug build -> fine. (Left side)

I suspect that apply of SetScriptingDefineSymbolsForGroup is too late.

I think SetScriptingDefineSymbolsForGroup is applied after methods_pointedto_by_uievents.xml is created.

Let me know what the problem in my project is?

Is it not safe to use SetScriptingDefineSymbolsForGroup?

Shoud i use way of modify mcs.rsp?

What is guide that recommend in build unity3d projects?