Native resolution fullscreen breaks UI clicks

Hello. I've been working on a game for a while now and this bug has appeared in my latest two builds (since moving to Unity 5.3). In fullscreen, at my native resolution, no mouse input goes through to the EventSystem (no highlights on buttons, no clicks on buttons, nothing.) Keyboard input still works correctly, and the game does detect mouse input correctly when unfullscreened at native or non-native resolution, and even in fullscreen at other resolutions (in case it's relevant my monitor is 2560x1440). Is this a 5.3 bug? Is it my monitor resolution? Perhaps most importantly, will anyone I send this build to experience the issue as well?
Edit: After doing a little testing, I discovered that on my other two monitors the game works fine at native fullscreen, leading me to believe it's an issue with my resolution. Still looking for a solution however.